Dose Analysis of Gadolinium Neutron Capture Therapy (GdNCT) on Cancer Using SHIELD-HIT12A
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چکیده
منابع مشابه
Evaluation of the relative biological effectiveness of the Auger electrons produced during gadolinium neutron capture therapy using microdosimetric approach
Determination of the relative biological effectiveness (RBE) of Auger electrons is a challenging task in radiobiology. In this study, we have estimated the RBE of internal conversion (IC) and Auger electrons released during Gadolinium neutron capture reaction (GNCR) by means of biological weighting functions (BWFs) with microdosimetric approach. Regarding the different distribution of Gadoliniu...
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OBJECTIVE Gadolinium neutron capture therapy (GdNCT) is a potential treatment for malignant tumors based on two steps: (1) injection of a tumor-specific (157)Gd compound; (2) tumor irradiation with thermal neutrons. The GdNC reaction can induce cell death provided that Gd is proximate to DNA. Here, we studied the nuclear uptake of Gd by glioblastoma (GBM) tumor cells after treatment with two Gd...
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157Gd is a potential agent for neutron capture cancer therapy (GdNCT). We directly observed the microdistribution of Gd in cultured human glioblastoma cells exposed to Gd-diethylenetriaminepentaacetic acid (Gd-DTPA). We demonstrated, with three independent techniques, that Gd-DTPA penetrates the plasma membrane, and we observed no deleterious effect on cell survival. A systematic microchemical ...
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Boron Neutron Capture Therapy (BNCT) can be performed at a facility with a nuclear reactor or at hospitals that have developed alternative neutron sources. A beam of epithermal neutrons penetrates the brain tissue, reaching the malignancy. Once there the epithermal neutrons slow down and these low-energy neutrons combine with boron 10 (delivered beforehand to the cancer cells by drugs or antibo...
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Introduction: Boron neutron capture therapy (BNCT) is recommended to treat the glioblastoma tumor. It is well known that neuron beams are more effective treatment than photon beams to treat hypoxia tumors due to interaction of neutron with nucleus and production of heavy particles such as 7Li and alpha particle. In this study to evaluate the suitability of BNCT for treating of ...
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ژورنال
عنوان ژورنال: ASEAN Journal on Science and Technology for Development
سال: 2018
ISSN: 2224-9028,0217-5460
DOI: 10.29037/ajstd.543